[Answer] Which of the following would be inhibited by a drug that specifically blocks the addition of phosphate groups to proteins?

Answer: receptor tyrosine kinase activity
Which of the following would be inhibited by a drug that specifically blocks the addition of phosphate groups to proteins?

A protein kinase inhibitor is a type of enzyme inhibitor that blocks the action of one or more protein kinases. Protein kinases are enzymes that add a phosphate group to a protein and can modulate its function. The phosphate groups are usually added to serine threonine or tyrosine amino acids on the protein: most kinases act on both serine and threonine the tyrosine …

An enzyme inhibitor is a molecule that binds to an enzyme and decreases its activity.By binding to enzymes’ active sites inhibitors reduce the compatibility of substrate and enzyme and this leads to the inhibition of Enzyme-Substrate complexes’ formation preventing the catalysis of reactions and decreasing (at times to zero) the amount of product produced by a reaction.

Botulinum toxin (Botox) is a neurotoxic protein produced by the bacterium Clostridium botulinum and related species. It prevents the release of the neurotransmitter acetylcholine from axon endings at the neuromuscular junction thus causing flaccid paralysis. The toxin causes the disease botulism.The toxin is also used commercially for medical and cosmetic purposes.

Bcr-Abl tyrosine-kinase inhibitors (TKI) are the first-line therapy for most patients with chronic myelogenous leukemia (CML). More than 90% of CML cases are caused by a chromosomal abnormality that results in the formation of a so-called Philadelphia chromosome.This abnormality was discovered by Peter Nowell in 1960 and is a consequence of fusion between the Abelson …

O-GlcNAc (short for O-linked GlcNAc or O-linked β-N-acetylglucosamine) is a reversible enzymatic post-translational modification that is found on serine and threonine residues of nucleocytoplasmic proteins .The modification is characterized by a β-glycosidic bond between the hydroxyl group of ser…

Leave a Reply