[Answer] Which of the following triggers the cell’s passage past the G2 checkpoint into mitosis?-protein kinase-PDGF-cyclin-Cdk-MPF

Answer: MPF
Which of the following triggers the cell’s passage past the G2 checkpoint into mitosis?-protein kinase-PDGF-cyclin-Cdk-MPF

Cell changes in the cell cycle like the assembly of mitotic spindles and alignment of sister-chromatids along the spindles are induced by M cyclin – Cdk complexes. The destruction of M cyclins during metaphase and anaphase after the Spindle Assembly Checkpoint is satisfied causes the exit of mitosis and cytokinesis. [6]

G1/S transition – Wikipedia

G0 phase – Wikipedia

Similar to S Phase G2 experiences a DNA damage checkpoint . The cell is once more examined for sites of DNA damage or incomplete replication and the kinases ATR and ATM are recruited to damage sites. Activation of Chk1 and Chk2 also transpire as well as p53 activation to induce cell cycle arrest and halt progression into mitosis.

The G1/S transition is a stage in the cell cycle at the boundary between the G1 phase in which the cell grows and the S phase during which DNA is replicated. It is governed by cell cycle checkpoints to ensure cell cycle integrity and the subsequent S phase can pause in response to improperly or partially replicated DNA. During this transition the cell makes decisions to become quiescent …

Maturation-promoting factor (abbreviated MPF also called mitosis-promoting factor or M-Phase-promoting factor) is the cyclin-Cdk complex that was discovered first in frog eggs. It stimulates the mitotic and meiotic phases of the cell cycle. MPF promotes the entrance into mitosis (the M phase) from t…

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