[Answer] miRNAs can control gene expression by what action?

Answer: binding to mRNAs and degrading them or blocking their translationmiRNAs can effectively “silence” genes by binding to mRNA transcripts. The mRNAs are either broken down by enzymes or are unable to physically interact with the ribosomes to complete translation.
miRNAs can control gene expression by what action?

The first miRNA was discovered in the early 1990s. However miRNAs were not recognized as a distinct class of biological regulators until the early 2000s. miRNA research revealed different sets of miRNAs expressed in different cell types and tissues and multiple roles for miRNAs in plant and animal development and in many other biological processes. Aberrant miRNA expression are implicated in disease states. MiRNA-based therapies are under investigation.

By binding to specific sites within the 3′-UTR miRNAs can decrease gene expression of various mRNAs by either inhibiting translation or directly causing degradation of the transcript. The 3′-UTR also may have silencer regions that bind repressor proteins that inhibit the expression of …

Gene expression is the process by which information from a gene is used in the synthesis of a functional gene product that enables it to produce protein as the end product. These products are often proteins but in non-protein-coding genes such as transfer RNA (tRNA) or small nuclear RNA (snRNA) genes the product is a functional RNA. Gene expression is summarized in the …

RNA silencing – Wikipedia

Small interfering RNA – Wikipedia

microRNA – Wikipedia

Small interfering RNA – Wikipedia

Thu Apr 08 2004 14:30:00 GMT-0400 (Eastern Daylight Time) · The upregulation of gene expression can partially be explained by the predicted gene targets of endogenous miRNAs . Computational analyses of more than 150 siRNA transfection experiments support a model where exogenous siRNAs can saturate the endogenous RNAi machinery resulting in the de-repression of endogenous miRNA-regulated …

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