[Answer] How is the destroying of cells used to evade host defenses?

Answer: Some viruses, such as HIV, actually infect and destroy the cells of the
immune system themselves
How is the destroying of cells used to evade host defenses?
Every 2–3 years a variant arises with mutations that allow the virus to evade neutralization by antibodies in the population; other mutations affect epitopes that are recognized by T cells and in particular CD8 T cells so that cells infected with the mutant virus also escape destruction. Individuals who were previously infected with and hence are immune to the old variant are thus susceptible to the new variant.
And like HIV coronaviruses have ways of undermining host defenses —SARS-CoV-2 for example also grabs onto handles in our defense proteins and disarms them. There are thousands of other coronaviruses in bats and other animals that have not crossed over to humans. Others have induced only mild colds and more serious ones such as SARS and …
Parasites have evolved a variety of ways to evade macrophages and other immune cells for example by modulating the host’s cell cytoskeleton to block proper phagocytosis. As an example Yops proteins are deployed by Yersinia pestis to interfere with macrophages ( Hornef et al . 2002 ); Shigella induces apoptosis in macrophages with proteins (e.g. IpaB) that also affect host cell shape ( Hilbi et al . 1997 ).
Viruses can evade host defence responses through the modulation of MHC molecules. T cells and NK cells recognise antigen presented in small fragments by MHC molecule. Once activated NK cells and Cytotoxic T cells kill cells infected with virus. Epste…

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