[Answer] How is Iron used to evade host defenses?

Answer: Iron is important to the organism’s survival- many can steal it from host
carrier-proteins
How is Iron used to evade host defenses?
Iron is an essential component of metabolism in both the host and the micro-organism. Thus to protect itself from such virulence mechanisms the host cell fights back by synthesising siderocalin receptors which competitively bind iron.
Host defenses that protect against infection include. Natural barriers (eg skin mucous membranes) Nonspecific immune responses (eg phagocytic cells [neutrophils macrophages] and their products) Specific immune responses (eg antibodies lymphocytes) (See also Overview of the Immune System. Overview of the Immune System The immune system …
Both animals and bacteria require iron for metabolism and growth and the control of this limited resource is often used as a tactic in the conflict between pathogen and host. Animals have evolved mechanisms of “withholding” iron from tissue fluids in an attempt to limit the growth of invading bacteria.
At low doses early in the infection LT acts to evade a number of host immune responses by suppressing pro-inflammatory cytokines the release of NOx (a toxic molecule) and TNF-α by macrophages DC responses and B- and T-cell deployment. LT has also been found to lyse macrophages induce apoptosis of endothelial cells and interfere with antigen pre…

Leave a Reply