[Answer] A 20-year-old man with respiratory depression is brought to the emergency department by his parents. The parents state that “[They] found him at home with various needles and syringes around him but [they] have no idea what he took.” Opioid overdose is suspected and an initial dose of naloxone is administered at 10 p.m. The patient does not respond to this initial dose. The team would expect to administer a second dose after how many minutes?